Gel-One® Cross-linked Hyaluronate

Gel-One Cross-linked Hyaluronate is a sterile, transparent, viscoelastic hydrogel approved for the treatment of pain in osteoarthritis (OA) of the knee. The unique cross-linking process allows for safe and effective pain relief in a single 3mL injection.

Gel-One Hyaluronate is a simplified single-injection treatment designed to support patients suffering from osteoarthritis of the knee regain their active lifestyles.

In a clinical study, patients receiving Gel-One Hyaluronate experienced, on average, a nearly 40% reduction in pain from baseline.1

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1. Stand, et al. A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee. Osteoarthritis and Cartilage. 20: 350-56, 2012.

Before using Gel-One Hyaluronate, ask your patients if they are allergic to hyaluronan products, cinnamon, or products from birds such as feathers, eggs, and poultry. Gel-One Hyaluronate is only for injection into the knee, performed by a doctor or other qualified health care professional. Gel-One Hyaluronate injection should not be used in the presence of skin disease or infection around the area where the injection will be given. Gel-One Hyaluronate has not ben tested to show pain relief in joints other than the knee or for conditions other than OA. Gel-One Hyaluronate has not been tested in patients who are pregnant, mothers who are nursing, or anyone under the age of 21. Strenuous or pro-longed weight-bearing activities after treatment are not recommended. The effectiveness of repeat treatment cycles of Gel-One Hyaluronate has not been established. The side effects most commonly seen after injection of Gel-One Hyaluronate in the clinical trial were knee pain, swelling, and/or knee effusion. These reactions are generally mild and do not last long. For complete instructions for use, see the package insert and visit

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